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疼痛與炎癥研究

鉗式測痛儀

時間:2016-09-19來源:本站作者:玉研儀器

詳細介紹

IITC 鉗式測痛儀是根據 Randall-Selitto 理論設計,是進行炎癥足加壓實驗的經典儀器。


型號:2450型


根據 Randall-Selitto 法,將藥物添加在小實驗動物的炎癥足上。Randall-Selitto 測痛儀測量單元具有壓力傳感器,并通過液晶屏實時顯示測量參數。壓力施加器一端為彈性的尖形探頭,另一端平坦。使用時將動物足部放入壓力施加器中間,對準探頭,施加壓力。逐步提高作用于動物爪子上的機械壓力,逼近動物的疼痛閾限,當動物出現縮足反應時,儀器自動測量并記錄最大壓力信號,以g為單位。

與熱痛不同,該儀器用于機械壓痛和鈍痛的痛覺測量,常用于辨別左右爪不同的痛覺反應。

鉗式測痛儀的產品特點:


適用于大鼠和小鼠精確度為0.01克
最大壓力400克數字顯示功能,實時壓力、最大值,單位為g
配置腳踏控制器,控制啟動下次實驗,解放雙手,提高實驗效率可選的動物固定支架,可輕松固定動物
方便操作測量誤差小于0.5%,不需校準,采用RS-232輸出方式


鉗式測痛儀 Rodent Pincher Analgesia Meter 

Rodent Pincher allows researchers to measure and test pain threshold in a simple, accurate method when measuring pain nociception.

The system can be used on mice or rats and will measure and display in grams the amount of force that has been applied to the animals paw.

Accuracy is .01 grams, no calibration needed.

One year warranty, CE certified


Description


Rodent Pincher System Analgesia Meter complete

Rodent Pincher - Pincher only



相關文獻:


[HTML] Coupled activation of primary sensory neurons contributes to chronic pain

YS Kim, M Anderson, K Park, Q ZhengA Agarwal… - Neuron, 2016 - Elsevier

… reported low incidence of neuron-neuron dye-coupling after CFA injection in the mouse paw
and … of naive, CFA, CFA with CBX, sham, SN-CCI, and SN-CCI with CBX animals by rodent pincher … CreER mice, which is present in glial cells in the peripheral nervous system such as …


[HTML] Imaging large-scale cellular activity in spinal cord of freely behaving mice

KJ Sekiguchi, P Shekhtmeyster, K Merten… - Nature …, 2016 - nature.com

… was recorded during rest (left) and following cutaneous stimulation with a rodent pincher applied
to … Mouse running speed (black) and tail pinch application (purple) is shown on top … Previous studies
in anaesthetized rodents, using two-photon imaging of non-selective synthetic or …



Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model

R Sarabia-Estrada, A Ruiz-Valls, SR Shah… - … of Neurosurgery: Spine, 2017 - thejns.org

… Nociceptive response was evaluated using the rodent pincher analgesia meter (Part # 2450,
IITC Life Science … chordoma models derived from human tissues have been used to produce rodent
tumors; however … is a lack of studies on pathologic gait due to chordomas in rodents …


 


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