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生理信號測量

大小鼠腦電記錄儀

時間:2016-09-28來源:本站作者:玉研儀器

詳細介紹

我們可以提供三通道和四通道的系統,用于研究自由活動狀態下小鼠和大鼠的睡眠、癲癇、行為模式研究。腦電/肌電系統利用特色的頭戴式的前置放大器,即使在動物運動時也能得到非常清晰的波形圖,四通道具有所有三通道的特征,并額外增加一個通道,配置靈活,具有同時配置生物傳感器的能力。


  • 用于實時監測動物腦電、肌電、化學物質的濃度(谷氨酸、葡萄糖、乳酸、乙醇、膽堿、總生物胺)
  • 可實現動物自由活動狀態下實時監測
  • 實現信號遙測功能,動物可放于迷宮內,實時監測腦內化學物質的濃度

大小鼠腦電記錄儀可以對自由活動狀態下的大小鼠睡眠、癲癇和一般行為范式研究提供了一套專業的生物電記錄系統。使用固定于動物頭部的前置放大器(Headstage)進行信號放大,即使在動物活動時也可以持續記錄到極低噪音的理想信號。

我們提供了一套預先配置好的三通道研究系統,可用于睡眠或者癲癇研究。同時還可以提供一套更加靈活的四通道系統,整合了生物探頭,以便用于多種信號的同步記錄。所有系統都支持光遺傳學套件。常見應用:睡眠研究、癲癇研究、深部電極記錄、皮層記錄、場電位、認知研究

 
部分部件:
  • 頭部固定器


 

預制的大小鼠頭部固定器構件將連接了EEG或者EMG電極線的插件固定在微型板上。額外的兩個針的電極是用于4通道EEG的配置。預制的固定器構件減少了手術時間,并且允許電極的多重排列,提供了即插即用的導線連接方式。 

  • 前置放大器


 

通過一個螺絲釘將前放固定到動物的頭部。
高通濾波:0.5Hz EEG,10Hz EMG(睡眠研究);或1.0Hz EEG,10Hz EMG(癲癇)
增益:X100(睡眠),X10(癲癇)

  • 線纜系統


 

一根18英寸的線纜通過轉輪鏈接到前置放大器。線纜中的導線外層被一層金屬彈簧絲?;ぷ?。

  • 放纏繞萬向輪


 

防纏繞轉輪固定在動物籠頂部。轉輪的兩個插頭設置為允許活動桿朝不同方向可以平衡的轉動。

  • 數據采集和分析器

 

系統配備的一個數據調制和采集器(DCAS)提供了二級放大、濾波、數字化功能,最后經過USB線將數據傳輸到運行采集分析軟件的計算機上。

技術參數 3通道 4通道
采樣速率 200Hz-2KHz 200Hz-20Hz
低通濾波 10Hz-1KHz 20Hz-15KHz
ADC精度 14 16
輸入/輸出端口 1TTL I/O
3 模擬輸出
4TTL I/O
4模擬輸出







產品類型:
? 3通道:通過模擬信號輸出
? 4通道:全配置通道,集成生物傳感器,通過前置放大器的信號變換重新配置
4通道系統有著3通道系統所有的特征,除此之外還增加一個通道,配置靈活的同步生物傳感器。

 


可選配件:
? 生物傳感器
? 集成視頻同步記錄設備


腦化學物質實時監測??椋?/strong>

快速掃描循環伏安法(FSCV)電化學檢測系統,用于兒茶酚胺(i.e., dopamine, norepinephrine, and serotonin)的測量??梢雜糜誆飭孔雜汕逍鴉疃刺碌畝?。該遙測系統適用于小鼠。


    山东十一选五网上投注:

    FAST SCAN CYCLIC VOLTAMMETRY SYSTEM

    山东十一选五十一月6号开开奖结果 www.ltsjdr.com.cn Pinnacle’s FAST SCAN CYCLIC VOLTAMMETRY (FSCV) SYSTEM is specifically designed to simplify the measurement of catecholamines (i.e., dopamine, norepinephrine, and serotonin). Pinnacle offers turn-key systems for both mice and rats. Both the wireless rat system and the tethered mouse system use carbon fiber sensors to enable short-term measurement in the brains of freely moving animals.




    HOW IT WORKS

    Biogenic amine levels are detected by rapidly cycling a voltage across an implanted carbon fiber sensor and measuring the resultant current. Our systems can measure spontaneous sub-second neurotransmitter release events while conducting detailed behavioral studies. Both the wireless and tethered systems sweep from 250 to 400 V/s in a user-selectable range spanning -1.1 to +1.3 V. All systems have built-in support for controlling an external stimulus.

    l  Voltage Span: -1.1 V to +1.3 V

    l  Range: 250 – 400 V/s 

    l Sweeps/second: 5 - 10 

    l Points/sweep: 1000 



    Analysis

    Dopamine (blue), serotonin (green), and norepinephrine (pink) have specific voltammogram profiles when detected by FSCV.


    The TETHERED FAST SCAN CYCLIC VOLTAMMETRY (FSCV) SYSTEM allows researchers to harness the powerful genetics of the mouse model to address underlying mechanisms of biogenic neurotransmitter release and function. A headmounted FSCV board sends signals through a low-torque commutator to an interface box that streams data to the host PC. The system comes with Pinnacle’s FREE 8500 software.



    1. The FSCV interface box provides access to stimulus lines and transmits data to PAL-8500 software.

    2. A low-torque commutator, which is mounted above the cage, allows for unencumbered freedom of movement.

    3. Signals are amplified and filtered at the head of the animal using our headstage, which ensures the delivery of clean, artifact-free data.

    4. Stereotaxically placed guide cannulas allow easy insertion of carbon fiber sensors. Headmounts are affixed to the skull with dental acrylic and act as a connection port for the headstage.

     




    CARBON FIBER


    Pinnacle’s FSCV system uses CARBON FIBER SENSORS (CFSs) to measure the presence of dopamine and other catecholamines in the brains of freely moving animals. Our sensor is a 34 μm diameter carbon fiber housed in a silica sheath that extends 0.5 mm beyond the end of the silica. All Pinnacle CFSs require an Ag/AgCl reference electrode.


    Our sensor is a 34 um diameter carbon fiber housed in a silica sheath that extends 0.5 mm beyond the end of the silica.

     




    CARBON FIBER SENSORS

    Carbon fiber sensors are ordered by cannula type and whether the researcher needs to remove them from the cannula for post-calibration. CFS-F sensors are fixed in the cannula and cannot be removed for post-calibration。



    FSCV PAL-8500 SOFTWARE PACKAGE

    The FSCV system includes Pinnacle’s FREE PAL-8500 software, which supports traditional, short recording paradigms (recordings of two minutes or less) as well as longer-term recordings that use an extended continuous mode. Furthermore, the suite supports integrated, synchronized video recording, which allows monitoring of animal behavior simultaneously with biogenic amine release.

     


    Additional features of this software include:
    ? Background Subtraction
    ? 3D Visualization 
    ? User-Selectable Filters 
    ? Heat Maps 
    ? Animated Voltammograms
    ? Export to Third-Party Packages 




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